Chloe Lopez-Lee, Ph.D.

Postdoctoral Fellow investigating how biological sex affects the brain during aging and disease

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© Chloe Lopez-Lee. All rights reserved.

How does biological sex shape the brain's responses to disease?

My work strives to parse apart how primary factors of biological sex, such as sex chromosomes and hormones, affect the brain in the presence of aging and Alzheimer's disease.Future investigation will expand to explore the boundaries of sex-biased effects in other dementias, such as vascular dementia.

Selected Publications:

• Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination. (2024). Science.

• Mechanisms of sex differences in Alzheimer’s Disease. (2024). Neuron.

• Sex differences in neurodegeneration: the role of the immune system in human. (2021). Biological Psychiatry.

• Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. (2024). Neuron.

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About

Chloe grew up in New York City and attended Mount Holyoke College, where she earned a Bachelor's degree in Neuroscience and conducted research on Alzheimer's disease using a fruit fly model. She then earned her Ph.D. in Neuroscience from Weill Cornell Medicine, elucidating sex differences in models of aging and tauopathy. As a graduate student, Chloe was selected for the HHMI Gilliam Fellowship and an NIH F31 award. Chloe is currently a postdoctoral fellow at Mount Sinai. In her free time, Chloe enjoys trying new cuisines and whale watching!

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